How effective is docetaxel for advanced prostate cancer?

How effective is docetaxel for advanced prostate cancer?

After a median follow up of 50 months, the median OS achieved in the docetaxel plus ADT arm was 58.9 months compared with 54.2 months in the ADT arm [HR: 1.01; 95% CI (0.75, 1.36); p = 0.955].

Can abiraterone cure prostate cancer?

Abiraterone won’t cure your prostate cancer, but it can help keep it under control and has been shown to help some men live longer. It can also help to treat or delay symptoms, such as pain and tiredness.

How many times can you have chemotherapy for prostate cancer?

It’s usually fine to start chemotherapy any time up to three months after starting hormone therapy. If you’ve already had hormone therapy, chemotherapy is usually given as a course of up to 10 sessions. But this might not be the same for everyone. You’ll usually have treatment every three weeks.

How long do you have to take abiraterone?

by Zytiga (abiraterone acetate) is a hormone therapy taken in combination with prednisone to treat prostate cancer that has already spread (metastasized) to other parts of the body. Patients typically take medications such as Zytiga for as long as they are effective for or as long as they can tolerate them.

Can abiraterone stop working?

After some months or years the hormone treatment usually stops working and the cancer starts to grow again. Your doctor might recommend stopping or changing hormone treatment at this stage. If you’re having anti androgens and your PSA level has started to rise again your doctor might get you to stop taking them.

Does docetaxel lower PSA?

A few studies have demonstrated that docetaxel rechallenge is a viable treatment option for patients who have a progression-free interval of >6 months and a ≥ 50% reduction in PSA levels during the first-line chemotherapy with docetaxel.

What If docetaxel does not work?

Types of Chemotherapy Drugs If docetaxel does not work or stops working, cabazitaxel (Jevtana) may be used.

What does docetaxel therapy do in prostate cancer?

Docetaxel is used as a chemotherapy drug and is prescribed in cases of hormone-refractory metastatic prostate cancer, among many other cancers. It is used with the purpose of blocking the growth of the tumor, as it acts on the cancerous cells, preventing them from separating into two new cells.

Is enzalutamide better than docetaxel?

Results: Compared to subjects who received enzalutamide post-abiraterone, subjects who received docetaxel post-abiraterone had more bone metastases, more visceral metastases, higher baseline PSA, and had more frequent PSA tests while on-treatment. There were no significant differences in PSA30 (41% for enzalutamide vs.

How long can you take docetaxel for prostate cancer?

We found a robust and independent effect on OS by the number of docetaxel cycles administered in the setting of mCRPC. These data indicate that patients who appear to have clinical, radiological, or biochemical benefit by docetaxel should continue beyond 6 cycles as long as they tolerate their treatment well.

How effective is docetaxel?

Doses of 100 mg/m2 of docetaxel, administered over 1 hour every 3 weeks, produced an overall response rate of 50% (range, 41% to 58%) in 129 evaluable patients, with a median duration of 6 months (range, 2 to 17 months).

How many patients progress to mCRPC?

Surgical or chemical castration is the standard treatment and up to 85% of patients respond initially. An estimated 10% to 50% of cases progress to metastatic castration-resistant prostate cancer (mCRPC) within 3 years of diagnosis.

Is docetaxel life threatening?

Introduction. Docetaxel is an antimicrotubular taxane derivative used for treatment of a variety of solid tumors. Due to its cytotoxicity, docetaxel occasionally causes severe and life-threatening toxicities (1).

How quickly does docetaxel work?

This typically begins two to three weeks after treatment starts. This hair loss can be all body hair, including pubic, underarm, legs/arms, eyelashes, and nose hairs. The use of scarves, wigs, hats, and hairpieces may help. Hair generally starts to regrow soon after treatment is completed.

Can mCRPC be cured?

No cure yet exists for mCRPC, but prolongation of survival is possible with new treatments, some of which have been approved by the U.S. Food and Drug Administration (FDA) or are being evaluated in clinical trials. Read on to learn more about new treatments for CRPC.