Table of Contents
What are the strategies of metabolomics?
Metabolomics strategies cover two primary analysis platforms including “untargeted-discovery-global” and “targeted-validation-tandem” based on the objective of the study (Figure 1).
What are metabolomic biomarkers?
Metabolomic biomarkers (comprised of multiple co-related metabolites) are meta-biomarkers. They do not rely on quantification of a single metabolite; rather, they consist of defining patterns of abundance of multiple biomarkers.
What is a metabolomic study?
Metabolomics is defined as the systematic study of all chemical processes concerning metabolites, providing characteristic chemical fingerprints that specific cellular processes yield, by means of the study of their small-molecule metabolite profiles.
What are the advantages of metabolomics?
Studying the metabolome is advantageous for several reasons including, The metabolome provides the closest link to the phenotype of an organism. The analytical approaches are transferable across different biological systems. Metabolism is highly conserved across biology.
What are metabolomic changes?
These findings suggested that metabolomic changes in depression models are characterized by decreased neurotransmitter and increased kynurenine metabolite levels in the brain, decreased amino acid and increased corticosterone levels in blood, and imbalanced energy metabolism and microbial metabolites in urine.
Why do we study metabolomics?
Because metabolomics affords profiling of much larger numbers of metabolites than are presently covered in standard clinical laboratory techniques, and hence comprehensive coverage of biological processes and metabolic pathways, it holds promise to serve as an essential objective lens in the molecular microscope for …
What is metabolome profiling?
Metabolic profiling (metabolomics/metabonomics) is the measurement in biological systems of the complement of low-molecular-weight metabolites and their intermediates that reflects the dynamic response to genetic modification and physiological, pathophysiological, and/or developmental stimuli.