Table of Contents
What causes Landau-Kleffner syndrome?
What causes Landau-Kleffner syndrome in a child? Researchers are still learning what causes LKS. It may be caused by changes (mutations) in genes, or by the effects of the environment on certain genes. In some cases, it may be caused by changes in a gene called GRIN2A.
What are some symptoms of Landau-Kleffner syndrome?
Landau-Kleffner syndrome (LKS) is a condition that shows up during childhood, causing difficulties with speech and seizures. Children with LKS lose the ability to talk and understand speech. This loss is called aphasia. Many children with LKS also have seizures, episodes of uncontrolled body movement.
What is LKS syndrome?
Definition. Landau-Kleffner syndrome (LKS) is a rare, childhood neurological disorder characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electro-encephalogram (EEG).
How is Landau-Kleffner syndrome diagnosed?
Landau-Kleffner syndrome is commonly diagnosed using an electroencephalogram (EEG). This is a scan that shows the brain’s electrical waves. Other diagnostic tests may be used.
Is Landau Kleffner syndrome autism?
A subgroup of children with autism after initially normal developmental (autistic regression) is of particular interest. Landau-Kleffner syndrome is a rare syndrome of unknown etiology. Most patients appeared normal before the onset of the syndrome….
| Landau-Kleffner Syndrome | Autistic Regression | |
|---|---|---|
| Mutations | Yes-GRIN2A | No |
How do you treat Landau Kleffner syndrome?
How is Landau-Kleffner syndrome treated?
- Medications often used are steroids or a high dose diazepam at night.
- Sometimes continous seizures in sleep persist despite medication.
- Resective brain surgery is not usually an option.
- Speech therapy should be started immediately in children with LKS.
How is LKS diagnosed?
An EEG (electroencephalogram), and in many instances a prolonged EEG or video EEG to capture sleep, is needed to diagnose LKS. The EEG in children with this epilepsy syndrome is abnormal, especially as they enter sleep.
How many people have LKS?
It occurs in approximately one child in a million. The disease is more common in boys and does not usually run in families. LKS may also be referred to as: Acquired aphasia* of childhood with seizures.
Can Eses be cured?
For most young people an improvement is seen in ESES in the early teenage years. The EEG may return to normal during slow sleep. The seizures become less frequent and may even go completely. At about this time an improvement in speech and language skills and learning is also seen.
Are Aspergers and ADHD related?
With regard to ADHD and Asperger’s , there is a large overlap in symptomology. In my experience, roughly 60-70 percent of children with Asperger’s Syndrome have symptoms which are compatible with an ADHD diagnosis. In fact, so common are ADHD symptoms in PDD that the PDD diagnosis technically subsumes ADHD.
What does Eses look like?
It shows continuous spike and slow wave epileptic activity during sleep, especially during part of sleep called ‘slow wave’ sleep. This is often continuous and lasts for many minutes, even for the whole time the child is in slow sleep. This is why ESES is also called ‘continuous spike-wave of slow sleep’ (CSWSS).
How do you treat Eses?
Treatment options for ESES/CSWS include some antiepileptic drugs (valproic acid, ethosuximide, levetiracetam, and benzodiazepines), steroids, immunoglobulins, the keto- genic diet, and surgery (multiple subpial transections).
Can you outgrow Eses?
Technically, ESES is considered a benign epilepsy, in that the seizures almost always resolve by the time the child reaches puberty. However, the damage done to the child’s development and the resulting neuropsychiatric deficits are often permanent.
How do u know if your child has Aspergers?
Signs your child may have Asperger’s syndrome include:
- Obsessing over a single interest.
- Craving repetition and routine (and not responding well to change).
- Missing social cues in play and conversation.
- Not making eye contact with peers and adults.
- Not understanding abstract thinking.
What is Landau Kleffner syndrome?
Landau Kleffner syndrome (LKS) is a rare childhood disorder characterized by the loss of language comprehension (auditory verbal agnosia) and verbal expression (aphasia) in association with severely abnormal electroencephalographic (EEG) findings during sleep and clinical seizures in most patients.
Is Landau-Kleffner syndrome the same as autism?
Landau-Kleffner syndrome isn’t autism. But diagnosing Landau-Kleffner syndrome vs. autism can be challenging because their symptoms are similar. Often, EEGs taken when your child is awake and when your child is asleep can distinguish between the two conditions.
What age does Landau-Kleffner syndrome start?
Landau-Kleffner syndrome is a rare language disorder. It often happens in normally developing children, usually between 5 and 7 years of age, and is characterized by the slow or sudden loss of the ability to use or understand spoken language. What are the signs of Landau-Kleffner syndrome?
How is Landau-Kleffner syndrome treated?
Healthcare providers may treat LKS with medication, speech therapy and behavioral therapy. What is Landau-Kleffner syndrome (LKS)? Landau-Kleffner syndrome is a condition that affects your brain by causing seizures and a loss or decline in speech and language skills.