What does osteoprotegerin bind to?

What does osteoprotegerin bind to?

Osteoprotegerin (OPG) is secreted by osteoblasts and osteogenic stromal stem cells and protects the skeleton from excessive bone resorption by binding to RANKL and preventing it from interacting with RANK. The RANKL/OPG ratio in bone marrow is thus an important determinant of bone mass in normal and disease states.

Who produces osteoprotegerin?

Osteoprotegerin produced by osteoblasts is an important regulator in osteoclast development and function. Endocrinology.

Is osteoprotegerin a protein?

OPG (osteoprotegerin) was identified as a gene/protein member of the tumor necrosis factor receptor (TNFR) superfamily secreted by osteoblastic cells by two independent groups [7,8] (Figure 32.1).

What causes osteoprotegerin?

Osteoprotegerin is a regulatory factor produced by bone marrow-derived stromal cells acting as a decoy receptor for the receptor activator of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) ligand (RANKL system).

Is osteoprotegerin a cytokine?

Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell.

What is OPG gene?

Osteoprotegerin (OPG), also known as osteoclastogenesis inhibitory factor (OCIF) or tumour necrosis factor receptor superfamily member 11B (TNFRSF11B), is a cytokine receptor of the tumour necrosis factor (TNF) receptor superfamily encoded by the TNFRSF11B gene.

Does osteoprotegerin inhibit RANKL?

OPG protects bone from excessive resorption by binding to RANKL and preventing it from binding to RANK.

What does OPG stand for in biology?

What does OPG do osteoporosis?

OPG deficiency causes osteoporosis in mice, and, when administered to ovariectomized rats, OPG decreases osteoclast activity and restores normal bone mass. OPG is produced by osteoblasts and arterial cells, and inhibits osteoclast function by neutralizing receptor activator of NF-kappa B ligand (RANKL).

Does estrogen produce osteoprotegerin?

Estrogen stimulates osteoprotegerin expression via the suppression of miR-145 expression in MG-63 cells – PMC. The .

Does osteoprotegerin activate osteoclasts?

Osteoprotegerin a novel secreted protein involved in the regulation of bone density. ), thus inhibiting osteoclast maturation.

What is the gold standard method of diagnosis for osteoporosis?

In the absence of a fragility fracture, BMD assessment by dual-energy x-ray absorptiometry (DXA) is the gold standard to diagnose osteoporosis, according to the classification of World Health Organization (WHO) [3].

What stimulates OPG release?

Estrogen stimulates OPG expression mainly at a transcriptional level through the estrogen receptor (ER), particularly ERα (13–15,18). Furthermore, an estrogen response element has been identified in the OPG promoter (19).

Does estrogen inhibit rankl?

Estrogen deficiency reduces the suppression of RANKL expression by bone lining cells, leading to increased osteoclastic bone resorption. Estradiol may also regulate OPG expression in bone lining cells.

What is the best and safest treatment for osteoporosis 2020?

Bisphosphonates are usually the first choice for osteoporosis treatment. These include: Alendronate (Fosamax), a weekly pill. Risedronate (Actonel), a weekly or monthly pill.