Table of Contents
What does RNA pol II do?
Eukaryotic RNA polymerase II (pol II) is a 12-subunit DNA-dependent RNA polymerase that is responsible for transcribing nuclear genes encoding messenger RNAs and several small nuclear RNAs (1).
What does RNA Pol II CTD phosphorylation do?
The C-terminal repeat domain (CTD), an unusual extension appended to the C terminus of the largest subunit of RNA polymerase II, serves as a flexible binding scaffold for numerous nuclear factors; which factors bind is determined by the phosphorylation patterns on the CTD repeats.
What is the role of Pol II CTD phosphorylation in the regulation of transcription and RNA processing?
The carboxy-terminal domain (CTD) of RNA polymerase II is that portion of the polymerase that is involved in the initiation of DNA transcription, the capping of the RNA transcript, and attachment to the spliceosome for RNA splicing.
What is the role of RNA polymerase II in the process of transcription in eukaryotes?
RNA polymerase II is responsible for transcribing the overwhelming majority of eukaryotic genes, including all of the protein-encoding genes which ultimately are translated into proteins and genes for several types of regulatory RNAs, including microRNAs (miRNAs) and long-coding RNAs (lncRNAs).
What is the purpose of phosphorylating the carboxy-terminal domain CTD of RNA polymerase II quizlet?
Phosphorylation of the repeat sequence in the CTP is important because it mediates interaction of capping and splicing factors and polymerase activity. The RNA polymerase II C-terminal domain (CTD) consists of multiple repeats of the heptapeptide sequence YSPTSPS, with the number of repeats varying among organisms.
What is the CTD composed of?
2.1 The CTD Is Composed of Heptad-Repeats In yeast and mammals, a single repeat in the CTD consists of a block of seven amino acids with the consensus sequence tyrosine-serine-proline-threonine-serine-proline-serine.
Which of the following is dependent on the C-terminal domain CTD of RNA polymerase II?
Rna, Transcription, And Translation : Example Question #7 Which of the following is not dependent on the C-terminal domain (CTD) of RNA polymerase II? Explanation: The correct answer is none of the other answers. Only mRNA transcribed by polymerase II undergo 5′ capping, polyadenylation, and splicing.
What is the role of the CTD in termination?
The CTD functions to help couple transcription and processing of the nascent RNA and also plays roles in transcription elongation and termination.
What are the functions of the CTD tail of RNA polymerase II quizlet?
What are the functions of the CTD tail of RNA polymerase II? splicing and capping of the 5′ and 3′ ends of the transcript.