What is beta-2 microglobulin test?

What is beta-2 microglobulin test?

This beta-2 microglobulin (B2M) test is used as a tumor marker for some people with blood cell cancers. It is not diagnostic for a specific disease, but it has been associated with the amount of cancer present (tumor burden) and can give a healthcare practitioner additional information about someone’s likely prognosis.

What is a normal beta-2 microglobulin level?

Normal findings : Blood: 0.70-1.80 mcg/mL. Urine: ≤300 mcg/L.

What is a high level of beta-2 microglobulin?

Tumor Markers The serum β2-microglobulin level is elevated (>2.7 mg/L) in 75% of patients at the time of diagnosis. Patients with high values have inferior survival. The prognostic value of serum β2-microglobulin levels in myeloma is probably due to two factors: High levels are associated with greater tumor burden.

What is the role of beta-2 microglobulin?

A function for beta 2-microglobulin as a modulator of lymphocyte surface and as a potential regulator of the immune system is proposed.

How do you diagnose multiple myeloma?

The diagnosis of multiple myeloma requires either:

  1. A plasma cell tumor (proven by biopsy)
  2. At least 10% of the cells in the bone marrow be plasma cells.
  3. M protein over a certain level in the blood (3g/dL)
  4. M protein in the urine over a certain level (1g/dL)
  5. Holes in bones due to tumor growth are found on imaging studies.

What is a BMG blood test?

The basic metabolic panel (BMP) is a blood test that gives doctors information about the body’s fluid balance, levels of electrolytes like sodium and potassium, and how well the kidneys are working.

Would a CBC show multiple myeloma?

Blood counts The complete blood count (CBC) is a test that measures the levels of red cells, white cells, and platelets in the blood. If there are too many myeloma cells in the bone marrow, some of these blood cell levels can be low. The most common finding is a low red blood cell count (anemia).

What is a high M spike?

A monoclonal spike (M spike or paraprotein) on serum protein electrophoresis (SPEP) is a frequent finding in the general population and typically is pathognomonic of an asymptomatic, premalignant condition called monoclonal gammopathy of undetermined significance (MGUS).

What is beta-2 glycoprotein test?

Beta-2 glycoprotein 1 antibody tests are primarily used along with cardiolipin antibody and lupus anticoagulant testing to help diagnose: Antiphospholipid syndrome (APS) The cause of an unexplained blood clot (thrombotic episode) The cause of recurrent miscarriages in women.

What causes high beta-2 globulin?

Conditions associated with an increased rate of cell production or destruction, severe infections, viral infections such as CMV (cytomegalovirus), and some conditions that activate the immune system, such as inflammatory conditions and autoimmune disorders, can cause increases in beta-2 microglobulin levels, but the …

Is beta-2 microglobulin the same as beta globulin?

Examples of beta globulins include: beta-2 microglobulin.

What tube is used for a BMP?

Gel-barrier tube (send entire tube) is preferred. Red-top tube or green-top (lithium heparin) tube is acceptable.

How do you diagnose APS?

To diagnose APS, the blood needs to be tested for the abnormal antiphospholipid antibodies that increase the risk of blood clots. This requires a blood test specifically designed to look for these antibodies.

What is Lac blood test?

What is a lactic acid test? This test measures the level of lactic acid, also known as lactate, in your blood. Lactic acid is a substance made by muscle tissue and by red blood cells, which carry oxygen from your lungs to other parts of your body. Normally, the level of lactic acid in the blood is low.

What is beta globulin blood test?

Healthcare providers use globulin blood tests to measure protein levels in your blood. Your liver makes globulin, a protein. High levels may indicate autoimmune disease, infections or cancer. A low globulin reading may be a sign of liver or kidney disease.

What does elevated beta 2 globulin mean?

Elevated beta 2 microglobulin in the blood is correlated with a larger amount of tumor (tumor mass) and reduced kidney function in multiple myeloma patients. Recently, the International Myeloma Working Group published new guidelines called the International Staging System for Multiple Myeloma.

What drugs are beta 2?

Beta-2 adrenergic agonists are a drug class used as a mainstay treatment for respiratory diseases such as bronchial asthma and chronic obstructive pulmonary disease (COPD). They replicate the functions of catecholamines such as epinephrine, norepinephrine, and dopamine in producing different autonomic responses within the body. Specifically, the smooth muscle of the airway, uterus, intestine

What causes high beta globulin levels?

Bone pain (myeloma).

  • Night sweats (lymphoproliferative disorders).
  • Weight loss (cancers).
  • Breathlessness,fatigue (anaemia).
  • Unexplained bleeding (lymphoproliferative disorders).
  • Symptoms of carpal tunnel syndrome (amyloidosis).
  • Fever (infections).
  • What causes elevated beta globulin levels?

    Beta globulins.Elevated beta-globulin levels may be indicative of chronic liver or kidney disease, or chronic inflammatory diseases such as aspergillosis or avian chlamydiosis.The most common reason for elevated beta globulins in birds, which is attributable to the transferrin component, is egg production.