Table of Contents
What is CD206 a marker of?
CD206 is a marker of alternatively activated macrophages, known as M2 macrophages.
What is MMR mouse?
The mouse Macrophage Mannose Receptor (MMR), also known as CD206 and MRC1 (mannose receptor C, type 1), is a 175 kDa scavenger receptor that is expressed on tissue macrophages, myeloid dendritic cells, and liver and lymphatic endothelial cells (1).
Where is CD206 expressed?
CD206 is a 175 kDa transmembrane protein encoded by the mannose receptor C-type 1 gene (MRC1). It is mostly expressed in macrophages, dendritic cells, and endothelial cells, where it functions as a receptor for mannosylated ligands, such as microbial antigens (27).
What is the function of M2 macrophages?
M2 macrophages play a central role in responses to parasites, tissue remodeling, angiogenesis, and allergic diseases (25, 92). Phenotypically, this population is characterized by the expression of the macrophage mannose receptor (MMR), also called CD206.
What is the marker of M2 macrophages?
CD163 and CD206 are major markers for the identification of M2 macrophages. Related surface markers for M2-type cells also contain CD68. Compared with marker CD68, CD163 is more selective to macrophages, so CD163 can be used as a highly specific marker for M2-type macrophages.
Do microglia express CD206?
It is mostly expressed in macrophages, dendritic cells, and endothelial cells, where it functions as a receptor for mannosylated ligands, such as microbial antigens (27). In neural tissues, expression of CD206 is observed in microglia (28, 29) and astrocytes (30, 31).
Can you use Crispr on mice?
CRISPR works in every strain of mouse, whereas ES-cell technology is mostly limited to one inbred strain. CRISPR’s impact is measured in more than savings.
Why are transgenic mice used?
Transgenic mice can also be used to study gene function or to generate models for human genetic disease, provided that the desired effect can be observed when the transgene is expressed in the presence of the multitude of host genes. In other words, dominant gain-of-function genetic alterations can be studied.
What are M2 markers?
Abstract. The alternatively activated or M2 macrophages are immune cells with high phenotypic heterogeneity and are governing functions at the interface of immunity, tissue homeostasis, metabolism, and endocrine signaling. Today the M2 macrophages are identified based on the expression pattern of a set of M2 markers.
What is the role of M2 macrophages?
M2 macrophages resolve inflammation, help tissue healing, tolerate self-antigens and certain neoantigens (for example apoptotic cells, symbiont cells, gametes and cells of the embryo in the uterus).
What is CD163 a marker for?
CD163 is a scavenger receptor, a member of the cysteine-rich family, which is a monocyte/macrophage-specific membrane marker. Specifically, CD163 is considered a marker of alternatively activated or anti-inflammatory macrophages (Abraham and Drummond, 2006; Komohara et al., 2006).