What is GN Crescentic?

What is GN Crescentic?

Crescentic glomerulonephritis, also known as rapidly progressive glomerulonephritis, is a condition of the kidney characterized by a rapid loss of renal function. On histological examination, it has the presence of numerous glomerular crescents (usually greater than 50%).

What is the type of primary Crescentic GN that is related to vasculitis?

Pauci-immune proliferative extracapillary GN When it is not part of a systemic disease and there is only renal involvement, it is also known with the names idiopathic crescentic GN, primary crescentic GN, or vasculitis limited to the kidney.

What are crescents on renal biopsy?

Crescents in renal biopsy are a result of insult to the glomerular capillary tufts due to the inflammatory mediators. As a result of the inflammatory insult, the parietal epithelial cells start proliferating and form crescents within the Bowman’s space.

What is the difference between acute glomerulonephritis and RPGN?

RPGN describes a clinical syndrome of rapid loss of renal function over days to weeks in patients with evidence of glomerulonephritis. In contrast, crescentic nephritis is a histopathologic description of kidney biopsy specimens that demonstrate the presence of crescents in more than 50% of glomeruli.

What is the prognosis of Crescentic glomerulonephritis?

The prognosis depends on the timeline of diagnosis and treatment. Although some patients requiring dialysis may recover a good renal function, usually the higher the serum creatinine at presentation the worse the outcome. When treatment is initiated early, most patients obtain a complete or partial remission.

What shape is a crescent?

A crescent is a curved shape that is wider in the middle than at its ends, like the shape of the moon during its first and last quarters.

What causes glomerular crescent?

The glomerular crescent is a histomorphological indicator of a rupture of glomerular capillaries, usually as a consequence of an intense immune attack involving cytotoxic elements, such as complement membrane attack complex and extracellular histones, that is, necroinflammation.

What causes crescent glomerulonephritis?

It is caused by an adaptive immune response to the foreign anti-GBM globulin (Odobasic et al., 2014; Ougaard et al., 2018). This phase is characterized by more severe injury and crescent formation due to the presence of cellular effectors including CD4 + T cells, macrophages, neutrophils and fibrin (Huang X. -R.

What is a crescent for kids?

Kids Definition of crescent (Entry 1 of 2) 1 : the shape of the visible part of the moon when it is less than half full. 2 : something shaped like a crescent moon. crescent.

What is the pathophysiology of glomerulonephritis?

Glomerulonephritis (gloe-MER-u-loe-nuh-FRY-tis) is inflammation of the tiny filters in the kidneys (glomeruli). The excess fluid and waste that glomeruli (gloe-MER-u-lie) remove from the bloodstream exit the body as urine. Glomerulonephritis can come on suddenly (acute) or gradually (chronic).

What are the different types of nephritis?

There are two main types of nephritis:

  • Glomerulonephritis, which involves damage to the filters in the kidney, is the most common.
  • Interstitial nephritis affects the space between tubules in kidneys, and commonly accompanies inflammation of tubules themselves, or tubulointerstitial nephritis.