Table of Contents
What is the Sonic hedgehog gene responsible for?
Normal Function. The SHH gene provides instructions for making a protein called Sonic Hedgehog. This protein functions as a chemical signal that is essential for embryonic development. Sonic Hedgehog plays a role in cell growth, cell specialization, and the normal shaping (patterning) of the body.
How Sonic the Hedgehog genes help control cell and limb differentiation in humans?
Shh has also been shown to control the width of the limb bud by stimulating mesenchyme cell proliferation and by regulating the antero-posterior length of the apical ectodermal ridge, the signaling region required for limb bud outgrowth and the laying down of structures along the proximo-distal axis (e.g., shoulder to …
Is Sonic hedgehog a transcription factor?
The sonic hedgehog transcription pathway has also been linked to the formation of specific kinds of cancerous tumors, including the embryonic cerebellar tumor and medulloblastoma, as well as the progression of prostate cancer tumours.
Where is the Sonic hedgehog protein found?
chromosome seven
SHH is located on chromosome seven and initiates the production of Sonic Hedgehog protein. This protein sends short- and long-range signals to embryonic tissues to regulate development.
How is Sonic hedgehog protein synthesized and processed in the endoplasmic reticulum?
Like all hedgehog proteins Shh protein also undergoes molecular processing in the endoplasmic reticulum. This involves cleavage of its signal peptide, followed by autocatalytic cleavage of the hedgehog protein precursor into a 19 kDa N-terminal domain (Shh-N) and a 25 kDa C-terminal domain (Shh-C).
What type of protein is sonic hedgehog?
Sonic Hedgehog Protein (SHH) is a protein within the Hedgehog family of growth factors. This monomer is encoded for by the shh gene and has a final translated product of approximately 462 amino acids and a molecular mass of 45 kDa.
What type of protein is Sonic hedgehog?
What type of protein is Sonic the Hedgehog?
How does the hedgehog pathway work?
The hedgehog signaling pathway is a mechanism that directs the development of embryonic cells in animals, from invertebrates to vertebrates. The hedgehog signaling pathway is a system of genes and gene products, mostly proteins, that convert one kind of signal into another, called transduction.
What is the role of hedgehog Signalling?
The Hedgehog signaling pathway is a signaling pathway that transmits information to embryonic cells required for proper cell differentiation. Different parts of the embryo have different concentrations of hedgehog signaling proteins. The pathway also has roles in the adult.
Is medulloblastoma fast growing?
Medulloblastomas are very fast-growing. They often spread to other areas of the CNS through cerebrospinal fluid (CSF). Rarely, medulloblastomas can spread outside the CNS to the bones or the lymphatic system.
What is hedgehog therapy?
ERIVEDGE® (Vismodegib of Genentech) capsule is a hedgehog pathway inhibitor indicated for the treatment of adults with metastatic basal cell carcinoma, or with locally advanced basal cell carcinoma that has recurred following surgery or who are not candidates for surgery or radiation.